Synthesis of Pyrazole Compounds

Pyrazoles are a class of substances with a wide range of biological activities. Our group tested two synthetic routes for the synthesis of acylpyrazoles from hydrazide and acylpyrazoles by acid acylation of the parent pyrazole. A total of 13 new pyrazole compounds were synthesized, all of which passed IR, UV, ~1H NMR. Characterized by means such as EA, the structure was confirmed by single crystal X-Ray diffraction analysis of four compounds. The results show that the acylpyrazole compound obtained by the reaction of the β-diketone and the hydrazide with the parent pyrazole and the acid chloride is an isomer of each other.